Correcting for Background Noise Improves Phenotype Prediction from Human Gut Microbiome Data
Published in Biorxiv, 2021
Recommended citation: Briscoe, L., Balliu, B., Sankararaman, S.,Halperin, E., & Garud, N. (2021). Correcting for Background Noise Improves Phenotype Prediction from Human Gut Microbiome Data. bioRxiv 2021.03.19.436199 (2021). doi:10.1101/2021.03.19.436199 https://doi.org/10.1101/2021.03.19.436199
We show that application of the centered log-ratio transformation prior to correction with unsupervised approaches improves prediction accuracy for many phenotypes while simultaneously reducing variance due to unwanted sources of variation.
Recommended citation: Briscoe, L., Balliu, B., Sankararaman, S.,Halperin, E., & Garud, N. (2021). Correcting for Background Noise Improves Phenotype Prediction from Human Gut Microbiome Data. bioRxiv 2021.03.19.436199 (2021). doi:10.1101/2021.03.19.436199